An inert matrix that is used to control the release of (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent.The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle.The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers.The Bread Mix results indicated that both methods of preparation were valid for incorporation PTX as a sustained release granules.
Moreover ,the results revealed that best polymer used was Eudragit RSPM in 3:20 ORTHO BONE polymer drug ratio.Besides to that , the results indicated that the release profiles were affected by pH- medium , PVP and EC addition as an enhancer or retardant polymer used respectively.As well as to the method of preparation.Key words : Pentoxifylline Sustained Retease , Eudragit RS , RL.